RELATED: Greatest Isekai Anime Of All Time
After huge titles like That Time I Got Reincarnated As A Slime gathered an immense fan base, countless Isekai anime following similar premises have been released. There are many anime to watch in this category, but there are a select few that top the charts of ones fans should binge next. Whether audiences love fantasy, sci-fi, drama, or comedy, the anime in this list are absolutely must-watches! Grab some popcorn and get ready for the best Isekai anime similar to That Time I Got Reincarnated As A Slime.
Updated November 12, 2021 by Jourdan Silva: The year 2021 was extra generous to fans of Isekai anime. So many great titles were released throughout the year, all with unique and exciting new plotlines and fantastical worlds for viewers to get lost in. This “best Isekai anime” list wouldn’t be complete without a few new additions that came from 2021. Fans of That Time I Got Reincarnated As A Slime will surely enjoy some of these new anime, which feature relatable characters, both hilarious and serious moments, quirky relationships, and thrilling plot twists and antagonists.
13 How A Realist Hero Rebuilt The Kingdom
In this series, a university student named Kazuya Souma is unexpectedly summoned into a fantasy world as a hero who will save a mighty kingdom dealing with many different threats. Rather than being the typical fantasy hero with a sword and magical skills, Souma uses his intellect and modern day political reform to help protect and strengthen the kingdom.
It’s entertaining to see a 21st century student use his knowledge to help the magical kingdom, which are filled with many different viewpoints than his own. It makes for a fun, interesting watch for many Isekai fans.
12 Tenku Shinpan (High Rise Invasion)
After 16-year-old Yuri Honjou is tragically faced with a masked assassin, she finds herself mysteriously trapped in an alternate universe. She is stuck in a high rise building with no signs of outside life, and a slew of masked murderers out for the blood of her and other transported victims.
RELATED: Best Isekai Anime For Fans Of The World’s Finest Assassin Gets Reincarnated In Another World As An Aristocrat
When she realizes her brother is also trapped in this chilling new world, Yuri gathers the strength to find him and try to escape. The anime is very unique and has an intriguing setting unlike any other. The series gets a bit wild and fast paced, making for a good binge.
11 Cheat Pharmacist’s Slow Life
This adorable Isekai anime follows the quirky story of Reiji Kirio, a normal guy who one day wakes up in a strange land with a questionable high knowledge on pharmaceuticals. He decides to make the best of it, and uses these new abilities to open his own drugstore alongside some new friends.
The series follows Reiji’s drugstore and the hectic days that he has to deal with in this new land. It’s not very deep and doesn’t feature any high-stakes, deadly threats like many other Isekai. It’s just a chill, fun, entertaining watch for those who want something easy and relaxing.
10 I’ve Been Killing Slimes for 300 Years and Maxed Out My Level
Protagonist Azusa passed away at a young age from overworking herself in the real world, and is reincarnated into a new, magical world in this series. She vows to not make the same mistake again and lives a peaceful, low-stress life for three centuries on her own.
Though Azusa wants to continue her quaint life, the decades of fighting off tiny slimes ended up maxing out her strength. Now, thanks to her skills, everyone knows about the girl boasting the maximum level. It’s colorful, fun, cheery, and exciting to watch.
9 Sword Art Online
In the near future, a popular virtual platform allows players to escape from the real world. However, the stakes are higher in this world than in most video games. The main duo, Kazuto “Kirito” Kirigaya and Asuna Yuuki, go through many dangerous and thrilling adventures throughout the virtual reality MMORPG world.
The show follows their battles, struggles, personal improvements, and the developments in their relationship. It’s one of those action-packed, addicting shows that viewers can put on and get lost in for hours.
8 RE:Zero
Normal citizen Subaru Natsuki finds himself transported to another world on the way home from the convenience store. He now faces the challenge of surviving in a fantasy world, where danger lurks in every corner.
RELATED: Best Isekai Anime Set In Games, Ranked
His unusual advantage is the power to turn back time whenever he dies, giving him the ability to twist the fates of his new friends and enemies. The show’s multiple relatable characters face many complex issues, resulting in personal growth and strengthening their relationships.
7 No Game No Life
Sora and Shiro, two siblings with too much time on their hands, are masters at video games and are bored with the real world. Now, they’ve been transported to a virtual world where conflicts are only resolved through intricate games.
The duo sets off on a quest to unite the new world, take down the current leader, and rule in his place. Some have criticized the show’s writing; however, the fast paced action scenes, flowing animation, and beautiful soundtrack keep fans raving for more.
6 The Rising of the Shield Hero
In this series, Naofumi suddenly vanishes from his school library and appears in a world that resembles a video game. Alongside three other boys his age from his world, he is equipped with a magical shield and tasked to save the fantasy land he is now stuck in.
There’s only one problem: the Shield Hero holds a tarnished reputation, and everyone hates him across the land. Naofumi must embark on a journey to level up and defeat the world’s terrible foes without the help of anyone in the kingdom. All he’s got are his few trustworthy sidekicks.
5 Overlord
This Isekai anime puts a different twist on the genre, with the main character being unapologetically evil. After years of playing a once-popular MMORPG that will soon shut down, Momonga gets stuck in the fantasy world, in the body of his all-powerful skeleton avatar.
RELATED: Isekai Anime To Watch Now That Re:Zero Season 2 Is Done
Trapped in the game he spent so much time playing, he faces dozens of sentient NPCs and deadly enemies. Momonga’s character is a joy to watch, having both a human side and an evil, demonic virtual side. He’s tough and scary, and acts as a villain in the story rather than a typical heroic protagonist.
4 Digimon Adventure
In this ever-popular classic anime from the 90s and remade in 2020, seven children are transported into a digital world where they can fight and evolve their Digimon while on a quest to save the new world they are stuck in.
This series’ target audience is younger than anime on this list. However, it’s still a fun-loving classic that everyone anime fan should watch at some point. Fans Pokemon will enjoy it in particular, as this feels like a high-tech version.
3 KonoSuba: God’s Blessing on this Wonderful World!
After Kazuma dies in the real world, a goddess named Aqua grants her a second life in a MMORPG-like world. The two enter the fantasy world together, where they must take down the land’s evil villain, the Devil King.
Accompanied by two other out-of-the-box party members, the highly dysfunctional team sers off on a journey to take down the Devil King and bring peace. It’s quirky, wild and worth the binge,.
2 Youjo Senki: The Saga of Tanya the Evil
The title character Tanya is the crooked, violent protagonist of this Isekai. She’s a small, blonde girl with combat skills beyond her age and appearance. Originally a man who was murdered in an alternate version of Europe, the protagonist’s soul was reborn in the form of Tanya, thus giving her these abilities.
RELATED: Winter 2021: Best Anime Characters Of The Season, Ranked
Tanya is a frighteningly cruel and sociopathic character, who brings a dark edginess to the genre. The anime revolves around war and other critical subject matter. It’s perfect for viewers who want something a bit more intense.
1 Isekai Quartet
For fans who enjoyed any of the anime listed above, then this Chibi crossover anime is surely one to hype them up. After the worlds of four different highly popular Isekai collide into one, the main characters from KonoSuba, Overlord, Re:Zero − Starting Life in Another World, and Saga of Tanya the Evil join together to engage in wild scenarios at a high school.
Soon after their arrival, characters from The Rising of the Shield Hero and Cautious Hero: The Hero Is Overpowered but Overly Cautious join the group as well. It’s a hilarious and adorable high school anime, involving vastly different characters across the Isekai genre.
MORE: Slice Of Life Anime To Watch If You Love Ijiranaide, Nagatoro-san
